Clearly, if noise bothers you, just use a tool like Nik Dfine.
The second example uses a layer mask so I can apply NR only to the places it's visible, and not to the places where I want to retain detail. Cool, huh?
These are crops from the center of each image. The full image at this magnification would print 60 inches (1.5 meters) wide.
Why this self-portrait? This is actually a very sneaky test: the fur on my face and eyes lets us see texture to look for the horrid effects of smudging from noise reduction, and the out-of focus wash behind my head lets us see noise at various levels on flat parts of the image. The out-of-focus transition behind my head is very deliberate.
I used the 105mm f/4 Micro-NIKKOR AI from 1980 because it's an ultra sharp lens, especially at the 1:8 reproduction ratio used here, and because it doesn't use floating elements or zoom. Its optical core is locked down solid, so nothing changes as put on different cameras with kludgy adapters. Newer macro lenses and zooms would all change their optical properties with floating elements as the flange focal distance varied slightly with the silly Nikon -> Canon adapter I used.
I left NR and sharpening at defaults. These are the actual images (JPGs) created by each camera. If you prefer to shoot raw, your results will vary all over the map depending on which software you use to anneal the raw files into actual images.
The 5D Mark II was running firmware version 1.0.7.
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